Follistatin 344 1mg

Follistatin, a single-chain gonadal protein, plays a crucial role in inhibiting the release of follicle-stimulating hormone (FSH). Encoded by the single FST gene, follistatin exists in two isoforms: FST317 and FST344, containing 317 and 344 amino acids, respectively, which arise from alternative splicing of the precursor mRNA.
Research indicates a potential linkage between polycystic ovary syndrome (PCOS) or hyperandrogenemia and follistatin. In a study involving 150 families and testing 37 candidate genes, evidence was found for a connection between PCOS and follistatin.
Functionally, follistatin acts as a direct binder to activin, thereby functioning as an antagonist to activin’s actions. It specifically inhibits the biosynthesis and secretion of pituitary follicle-stimulating hormone (FSH).
This information serves solely for research purposes and underscores the importance of further investigation into follistatin’s role in reproductive physiology and its potential implications for conditions like PCOS.