IGF-1LR3

Long[R3] insulin-like growth factor-I (IGF-1 Long[R3]) is a single, non-glycosylated polypeptide chain composed of 83 amino acids. It serves as an analog of human IGF-1, featuring the complete human IGF-1 sequence with a substitution of Arginine (Arg or R) for Glutamic Acid (Glu or E) at position 3 (hence R3), along with a 13 amino acid extension peptide at the N-terminus.
This engineered analog is designed to enhance biological activity, exhibiting significantly greater potency than IGF-1 both in vitro and in vivo. This heightened potency arises from the reduced binding of IGF-1 Long[R3] to all IGF binding proteins, which typically inhibit the biological actions of IGFs.
IGF-1, or insulin-like growth factor, is a naturally occurring substance in the human body, reaching peak levels during puberty. During this period, IGF-1 plays a pivotal role in driving natural muscle growth. Beyond muscle development, IGF-1 exerts various effects on the body:
– Increased amino acid transport to cells- Enhanced glucose transport- Elevated protein synthesis- Reduced protein degradation- Augmented RNA synthesis
These attributes underscore IGF-1’s multifaceted role in physiological processes and highlight its potential implications for research purposes.